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Herbal Medicine and Female Fertility  



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Many studies have demonstrated the value of micronutrients both alone and in combination with other therapies for treating female infertility. These micronutrients include anti-oxidants, B vitamins, vitamin D, and fatty acids (oleic acid, docosapentaenoic acid, eicosapentaenoic acid, and omega-3 and omega-6) as well as saturated and monounsaturated fatty acids. The propensity for women to utilize herbal medications is rising as a result of the harmful effects of chemical treatments on reproductive health, expensive drug costs, and cutting-edge fertility treatment techniques. 

Because it contains a variety of chemicals with phytoestrogens, antioxidants, and nutritional benefits, herbal medicine is seen to be a good alternative to pharmaceutical medications. One of the helpful and healthful methods to lessen the symptoms of menopause in women who are estrogen deficient is to utilize phytoestrogens that mimic estrogen.

Punica granatum (Pomegranate) 

Pomegranates, or Punica granatum, have spread to nearly every country on the planet, including those in Asia, the Middle East, and the Mediterranean. Pomegranate contains a lot of vitamin C, water, and polyphenols. Pomegranate seeds include phytoestrogens which was demonstrated to regulate and alleviate PCOS symptoms in an animal investigation on PCOS-affected rats. The extract of this plant thickens the uterine wall and improves mucus secretion by increasing uterine blood flow (vasodilation). This increase in mucosal secretions increases the rate of implantation via anti-inflammatory mechanisms.

In a randomized controlled triple-blind parallel trial investigation, it was discovered that pomegranate fruit extract improved the lipid profile and serum levels of sex hormones in 23 women with PCOS (reduced testosterone).

Matricaria chamomilla (Chamomile) 

Matricaria chamomilla, usually known as chamomile, is a member of the chicory family of plants. It includes flavonoids and antioxidants.

In a pilot study using 56 women with idiopathic hyperprolactinemia, those given chamomile syrup showed a reduction in prolactin levels after four weeks compared to those given a placebo, indicating that chamomile may play a role in regulating prolactin secretion in women by acting on dopamine receptors. 

Vitex Agnus‐castus (Verbenaceae)  

Vitex agnus castus, a member of the Verbenaceae family, has traditionally been used to treat acne as well as menstrual difficulties caused by corpus luteum deficit, such as spasmodic dysmenorrhea and premenstrual symptoms. Because of their high affinity for estrogen receptors, the bulk of these chemicals are isoflavones and flavonoids, which are beneficial for improving women’s sexual health. This plant’s flavonoids and isoflavones increase endometrial blood flow by increasing the release of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) from vascular endothelium.

The extract of this plant stimulates the corpus luteum to release progesterone after ovulation, which governs the female reproductive cycle. In an animal investigation, blood levels of estrogen and progesterone increased in the Verbenaceae extract group whereas levels of LH and prolactin—hormones that disrupt sexual function—decreased. In addition, when compared to the control group, a study in rats with induced PCOS found that this plant’s extract reduced the number of preantral and antral follicles as well as the corpus luteum after 28 days. Furthermore, the antral follicle diameter, follicular theca thickness, and ovarian tunica albuginea thickness all increased when compared to the control group.

Ashwagandha (Withania somnifera)

Ashwagandha, often known as Indian ginseng, is a Solanaceae plant that has been demonstrated to benefit women who are having difficulty getting pregnant. This wild plant can grow in dry, hot, and arid climates in the southern Mediterranean region, the Canary Islands, northern Africa, and northern India (Iran, Jordan, Sudan, Palestine, Afghanistan, and Egypt).

The majority of the plant’s components, isoflavones and flavonoids, have estrogenic effects. It was revealed that Ashwagandha extracts, through their GABA mimic properties, increased gonadotropin hormone release and, as a result, improved oogenesis, which was hypothesized to be due to improved hypothalamus function.

Phoenix Dactylifera (Date palm) 

The date palm, Phoenix Dactylifera, is a member of the palm family (Arecaceae), and its fruit has been employed in traditional Iranian, Roman, Egyptian, Chinese, and Greek medicine to improve sexual potency and pleasure in both sexes and lessen menopausal symptoms in females. This plant exhibits positive benefits in enhancing female fertility and contains vital elements including cobalt, copper, fluorine, magnesium, manganese, selenium, and zinc. It also contains vitamins (A, B1, B2, B3, B5, B6, B9, C, E, and K). 

The analysis of the fruit and seed of this plant showed the presence of polyphenolic compounds (isoflavonoids and flavonoids). According to studies, this plant’s saponins increase blood flow to the female reproductive system by producing NO and activating the HPG axis. 

The presence of gonadotropin-like biocomponents extract stimulates oogenesis and increases the number of antral and secondary follicles as well as the growth and maturation of preantral follicles, according to a study in mice. One study found that ingestion of P. dactylifera extract decreased the LH to FSH ratio and the number of cystic follicles, regulated estrogen, and androgen synthesis, and raised the number of secondary and antral follicles due to the presence of estrogen-like chemicals. It has been demonstrated that the estrogenic components of this plant extract can treat uterine problems by preventing endometrial tissue degradation, necrotic patches, and endometrial gland hyperplasia. 


Thirty-three of the 250 Cinnamomum genera found in the world today have medicinal and dietary benefits. 

Inflammation, PCOS, and boosting male and female sexual potency and female sexual desire are some conditions that have been successfully treated with cinnamon extracts and their powerful components polyphenols (flavonoids, and isoflavones).

Consuming plant extracts rich in polyphenols (isoflavonoids and flavonoids), such as cinnamon, which have anti-inflammatory and antioxidant characteristics will help slow the course of endometriosis and lower estrogen release. 

According to studies, women with PCOS who took Cinnamomum experienced improvements in their menstrual cycle, insulin resistance, and androgen secretion. Moreover, studies revealed that cinnamon can reduce estrogen secretion and prevent endometriosis progression via its antioxidant and anti-inflammatory properties. 

Nigella sativa (Black seed‐ Ranunculaceae) 

This plant, which has two to three pinnatisect leaves and a height of 30 to 60 cm, is a member of the Ranunculaceae family. The plant can be found growing all across the world, including Southeast Asia, West Asia, and Eastern Europe. Its many parts, including the seeds, leaves, flowers, and stem, are extracted and used to treat a variety of illnesses, including PCOS and male infertility. 

Polyphenols, particularly flavonoids, make up the majority of this plant’s active components. Several studies have demonstrated that Nigella sativa extract lowers the number of ovarian cysts in various animal models (rats and mice) of PCOS by inhibiting LH and estrogen release and increasing FSH levels. This is because the extract contains phytoestrogens and flavonoid components. 

Due to the presence of phytoestrogens, prolonged usage of N. sativa extract can lower testosterone levels, which can negatively affect LH. On the other hand, if androgen levels drop, LH production is likely to decline as well, lessening its dominance over FSH. Moreover, Nigella sativa extract may increase ovulation in PCOS women by decreasing LH dominance over FSH by blocking nitric oxide and leptin-releasing neurons that are directly implicated in the generation of LH from the anterior pituitary gland. 

Glycyrrhiza glabra (Licorice‐ Liquorice) 

Liquorice, also known as Glycyrrhiza glabra, is a herbaceous perennial plant in the Fabaceae family. Despite being a global plant, it is native to southern Europe and western Asia, including France, Uzbekistan, China, and Iran. 

Because of its high concentration of phytoestrogen compounds, this plant may be useful in the treatment of estrogen-dependent diseases such as breast cancer, endometriosis, PCOS, and Premature Ovarian Failure (POF). 

Licorice, can reduce testosterone synthesis and thus be used to treat women with PCOS. Furthermore, licorice extract was shown to improve ovarian morphology, oocyte maturation, and embryonic development in a study on PCOS-induced mice. 

Herbs, according to many herbalists, are often better, cheaper, and healthier than their medical counterparts. Many medical professionals, however, do not recommend herbal remedies because their safety has not been proven through extensive research. Natural herbs and vitamin supplements, unlike prescription drugs, are not subjected to the same level of scrutiny and evaluation by the Food and Drug Administration (FDA). As a result, the quality and strength of a herbal supplement can differ between batches of the same product and between products manufactured by different companies.  

Camellia sinensis (Chinese tea) 

Chinese tea, Camellia sinensis, is a member of the Theaceae family and is native to East Asia, the Indian Subcontinent, and Southeast Asia. However, it is now grown in tropical and subtropical locations all over the world. 

This plant’s compounds have antioxidant and phytoestrogen properties, and they restored the secretion and concentration of sex hormones such as LH, FSH, estradiol, and testosterone in female Wistar rats with letrozole-induced PCOS. Given that the aromatase enzyme is crucial for the synthesis of estradiol in ovarian granulosa cells, it has been demonstrated that the isoflavones from this plant inhibit granulosa cell production of this enzyme, which lowers estradiol production in a dose-dependent manner. 

Always seek medical advice from a qualified healthcare professional before using any herbal supplements.



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Exclusive Interview with The NET ZERO ENERGY Buildings Expert Anastasia Makarska: Shaping a Greener Future



Anastasia Makarska

Welcome to an exclusive interview with Anastasia Makarska, a renowned figure in the world of commercial real estate development. Anastasia’s resolute commitment to sustainability and her unique background in physics and engineering have revolutionized the real estate landscape, transforming spaces into sustainable and coveted marvels. 

In this interview, we delve into the concept of Net Zero Energy Buildings (NZEB) and the challenges associated with building codes for NZEB. Join us as we explore the visionary force behind Anastasia’s remarkable projects and her dedication to shaping a greener future.

Anastasia, thank you for joining us today. Let’s start by discussing the concept of Net Zero Energy Buildings. Could you explain to our audience what exactly is meant by a Net Zero Energy Building (NZEB)?

Anastasia: Certainly. A Net Zero Energy Building, or NZEB, is an approach to construction that focuses on creating energy-efficient buildings that are connected to the power grid while also generating renewable energy to offset their energy consumption. The aim is to achieve a balance where the amount of renewable energy produced either on-site or nearby matches or exceeds the building’s annual energy needs, resulting in virtually no net energy consumption.

That’s fascinating. It’s clear that NZEBs hold tremendous potential in terms of sustainability. How are developers and building owners embracing this concept, and what are some innovative features we can find in NZEBs?

Anastasia: Developers and building owners are increasingly interested in constructing zero energy buildings, driven by corporate objectives and regulatory requirements. The building and design community is actively embracing this challenge and leading the way with innovative and forward-thinking projects.

NZEBs incorporate a wide range of energy-efficient strategies, from simple to highly intricate. These include maximizing the utilization of passive solar heat gain and shading, integrating high-efficiency heating and cooling systems, appliances, windows, and doors, enhancing insulation, natural ventilation, air sealing, and incorporating advanced renewable energy solutions like solar photovoltaics and geothermal energy systems. 

The goal is to create buildings that regulate temperature fluctuations, minimize energy consumption, and reduce environmental impact.

It’s impressive how NZEBs combine various technologies and strategies to achieve sustainability. Now, let’s delve into building codes. What role do building codes play in the construction of NZEBs, and what codes and standards exist for this purpose?

Anastasia: Building codes play a crucial role in guiding the construction of net zero energy buildings. Currently, there are codes and standards in place to assist designers, architects, builders, and contractors in creating more energy-efficient and sustainable structures compared to previous years.

In the United States, professionals in the building industry can refer to the International Energy Conservation Code (IECC), which has been adopted in approximately 44 states and territories. Across North America, ASHRAE 90.1 provides significant guidance, and the International Green Construction Code (IgCC) serves as another valuable resource. In Canada, there are the National Energy Code of Canada (NECC) and the National Energy Code for Buildings (NECB).

That’s helpful to know. Given the increasing need for more rigorous energy and building codes, what are some of the challenges faced in developing codes specifically tailored for NZEBs?

Anastasia: The development of codes specifically tailored for NZEBs faces several challenges. As industry professionals and officials work on designing new codes to facilitate the transition to net zero energy, there is still no consensus on the structure of the code, its comprehensive scope, and ensuring that buildings achieve net zero energy status throughout their lifecycle.

To ensure buildings perform as intended, it is essential to establish post-construction reporting, analysis, and a framework for oversight and enforcement. 

Current codes and standards often rely on energy proxies without a requirement for actual quantification of energy usage. There are also gaps in the inclusion of certain types of energy usage in calculations. 

To achieve the goal of net zero energy buildings, methodologies need to evolve, modeling capabilities should be enhanced, and real-world outcomes must be measured.

Overcoming those challenges will be crucial for the success of NZEBs. Could you tell us about the advantages that net zero energy buildings offer to building owners, occupants, and the environment?

Anastasia: Absolutely. Net zero energy buildings provide several advantages. Buildings account for a significant portion of fossil fuel energy consumption and greenhouse gas emissions. By increasing the number of net zero energy buildings, we can reduce our dependence on fossil fuels and effectively lower carbon emissions.

Some key advantages of NZEBs include protection for building owners against future energy price hikes, enhanced occupant comfort, health, well-being, and productivity, reduction in energy consumption and associated costs, improved reliability of energy supply, increased resale value due to high demand for net zero buildings, contribution towards achieving zero energy targets, and minimized environmental impact. These advantages create value for building owners, occupants, and the planet.

Those advantages make a compelling case for embracing net zero energy buildings. As a visionary force in real estate development, how do you see the future of NZEBs and their potential impact on communities and the environment?

Anastasia: I believe the future of net zero energy buildings is incredibly promising. As awareness of the need for sustainability grows, NZEBs will become the norm rather than the exception. They have the potential to reshape communities and serve as catalysts for positive change.

Net zero energy buildings can create vibrant, sustainable communities that prioritize the well-being of both residents and businesses. By reducing energy consumption, minimizing environmental impact, and offering enhanced comfort and productivity, NZEBs have a transformative effect on the communities they serve. They not only contribute to the preservation of our planet but also provide value for investors, businesses, and communities alike.

Thank you for sharing your insights, Anastasia. Before we conclude, could you tell our audience about any upcoming projects or initiatives that you’re particularly excited about in the realm of net zero energy buildings?

Anastasia: Certainly. I’m thrilled to be working on a groundbreaking project that aims to create a net zero energy residential community. This community will embody the principles of sustainable living and showcase the potential of NZEBs on a larger scale. It will integrate cutting-edge technologies, energy-efficient systems, and sustainable materials to provide residents with an exceptional living experience while minimizing the community’s environmental footprint. I believe this project will serve as a blueprint for future developments and inspire others to embrace the vision of net zero energy living.


As we conclude this insightful interview with Anastasia Makarska, it is evident that she is a visionary force transforming the real estate industry through sustainable development. Anastasia’s dedication to creating sustainable and desirable spaces, her commitment to excellence, and her unwavering belief in the power of net zero energy buildings have positioned her as a leading authority in commercial real estate.

Through her innovative projects and expertise, Anastasia is shaping the world we live in, one groundbreaking project at a time. Her visionary approach, fueled by her unique background in physics and engineering, has redefined the boundaries of commercial real estate development and paved the way for a greener and more sustainable future.

Witness the remarkable journey of Anastasia Makarska as she continues to revolutionize the real estate landscape and leave an indelible mark on the communities she transforms into sustainable and coveted marvels.

If you would like to get in touch with Anastasia Makarska you can contact here

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Devin Millar Promotes the Normalization of Cross-dressing Through his Music



Devin Millar

An independent music producer, who’s name is Devin Millar, hailing from the Portland Oregon area is bringing a new approach to fashion, animation, and music.

Devin is on YouTube and creates animations to go with his music, which is modeled after 90s children’s animations with adult themes and references. He grew up his uncle Grayson, and with his parents, and Grayson showed him how to create Dance music which was how Devin got his music-making knowledge. Clothing-wise, he wears skirts and dresses similar to Melina Martinez, and is heavily inspired by her. He says he always felt like a kid even at the age of 22.

Devin claims that modern society should treat crossdressing the same as how women and girls are viewed when dressing the same way. Millar believes everyone should be understood and that skirts and dresses should become everyday clothing regardless of who is wearing it.

One view and song in particular, is “Doll Life”, a song Devin released which focuses on the main mascot of his music, Jack.

Jack is a teenage boy who dresses up like a girl as part of his feminine style and goes on an adventure with his friends to fight the underwater mafia in his Cadillac Escalade. Everyone becomes friends and all perform together. The song has been viewed many times on YouTube many times and has been a hit for the last couple of months. One may notice the boy characters also wear dresses with the girls and women, which are identical to the one Jack is wearing. For that reason, the song subliminally sends Devin’s message.

Promoting a sense of animated nostalgia and creating songs with happy tones mixed with Dance music through his YouTube channel, Devin has been creating melodic, inspiring Pop music since he was 14 and continues to inspire others. Devin is also on a mission to inspire the world to not label clothes and fashion based on gender.

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The Three Most Crucial Supplements to Take During the First Trimester of Pregnancy



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A healthy first trimester is critical to the normal growth of the fetus. You may not be exhibiting much on the exterior, but on the inside, all of the fetus’s vital organs and systems are developing.

Several changes occur as the embryo attaches itself to the uterine wall. During the first trimester, the fetus is most vulnerable to harm from substances such as alcohol, narcotics, and some medications, as well as infections such as rubella (German measles). Throughout the first trimester, both your body and your baby’s body are rapidly changing.

During the first trimester, the most dramatic changes and development occur. All nutrients are vital throughout pregnancy, but some are especially important for your baby’s growth and development.

Folic acid

Taking folic acid before and during early pregnancy can help avoid neural tube defects (NTDs), which are birth malformations of the brain and spine. According to some research, consuming folic acid may help prevent birth malformations in your baby’s mouth (called cleft lip and palate).
Spina bifida and anencephaly are the most common NTDs. In the United States, around 1,500 newborns are born with spina bifida each year. Spina bifida occurs when the small bones of the spine fail to close completely, and a portion of the spinal cord pokes through the spine. Children with spina bifida may have paralyzed legs and difficulty managing their bladder and intestines (going to the toilet).

One of the most severe NTDs is anencephaly. It affects approximately affecting about 1 in 1,000 pregnancies in the United States each year. However, because the majority of these pregnancies end in miscarriage, the prevalence of this disease in neonates is far lower. Anencephaly affects approximately one in every 10,000 infants in the United States. Anencephaly occurs when the upper portion of the neural tube that develops the brain does not completely seal. Major regions of the brain, skull, and scalp are missing in babies with this disease. They are usually only alive for a few hours after birth. Anencephaly affects girls three times more than boys.

Docosahexaenoic acid (DHA) 

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that promotes growth and development. DHA is required throughout pregnancy to aid in the development of your baby’s brain and eyes. DHA promotes the growth of the cerebrum, which is in charge of thinking, remembering, and feeling.

Autism and schizophrenia disproportionately afflict males and are closely linked to early life adversity caused by maternal stress and other variables, which may be influenced by nutrition. However, the fundamental causes of these male-specific effects are not fully understood. Researchers from the University of Missouri School of Medicine and the MU Thompson Centre for Autism and Neurodevelopment have discovered potential explanations for male vulnerability in the womb, and they’ve discovered that a specific maternal nutritional supplement called docosahexaenoic acid (DHA) may protect unborn males during early development from the effects of maternal stress.


Iodine is a mineral that your body needs to produce thyroid hormones, which aid in the usage and storage of energy from food. Additionally, iodine is required throughout pregnancy to aid in the development of your baby’s nervous system. Your baby’s neurological system (brain, spinal cord, and nerves) allows him or her to move, think, and feel.

During pregnancy, iodine requirements rise by 50%. A lack of iodine during pregnancy can result in maternal and fetal hypothyroidism, as well as impaired fetal neurological development. The effects are determined by the severity and timing of the hypothyroidism; the most severe symptom is cretinism.

Controlled studies in iodine-deficient areas have shown that iodine supplementation before or during early pregnancy eliminates new cases of cretinism, increases birth weight, lowers rates of perinatal and infant mortality, and improves developmental assessments in young children by 10-20%.


You’re not alone if you’ve never heard of Choline. Although it is suggested that it be included in all prenatal vitamins, most do not contain a significant quantity of Choline, if any at all. While Choline occurs naturally in foods such as cow liver and whole eggs, up to 95% of pregnant women do not consume enough prenatal Choline to meet their nutritional needs.

Choline is a “vitamin-like” important ingredient, which means that while it is not a vitamin, it functions similarly to one. Choline is necessary for optimal bodily function and is especially vital during pregnancy to support the adequate intake of Omega-3 DHA, general baby growth, and the mother’s personal health and wellness.

Furthermore, Choline prevents birth abnormalities. According to research, the lowest incidence of neural tube abnormalities is directly tied to the mother’s choline status during pregnancy.

Choline acts against factors that cause pregnancy problems preventing a variety of pregnancy complications, including low birth weight, pre-eclampsia, placental abruption, and recurrent pregnancy loss.

Furthermore, choline decreases the baby’s stress response, helps increase childhood visual memory, and improves motor performance in tasks that require accuracy. Additionally, prenatal choline supplementation enhances a child’s attention span.

You’re effectively working overtime to build a human being, thus a good, balanced diet is vital to compensate for this extra energy expenditure. Appropriate supplementation is essential to guarantee you’re meeting your higher prenatal vitamin demands.

Supplementation varies based on the particular woman, and it is strongly advised that all supplements be pre-approved by your doctor or medical expert.

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